Lymphatics are an Active Player in Major Healthcare Challenges

The lymphatic system—not the veins—is primarily responsible for returning capillary ultrafiltrate and plasma proteins to blood circulation. Review modern evidence on the central role of the lymphatics in chronic swelling.

• The lymphatics impact cardiovascular disease, immune function, cancer and possibly obesity.
• All chronic swelling reflects lymphatic inadequacy or failure.
• Left untreated, LE can lead to a spiral of worsening complications.